Endocrine Abstracts

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

Introduction: Noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) is an entity with low prevalence (4%), more frequent in neonates and infants and with a male preponderance, characterized by endogenous hyper insulinemic hypoglycemia, not caused by an insulinoma. Pancreatic histology usually reveals diffuse nesidioblastosis.Case report: A 21-years-old man without a remarkable personal or family history was referred describing a 15 kg weight g...

Introduction/aim: Neurological symptoms are rarely related to decompensated type 2 diabetes mellitus. However, thanks to complementary tests, we can identify this association more easily.Material and method: Review of the patient’s clinical record and the relevant literature.Results: A 76-year old man complained in the last year of a progressive, involuntary and disabling movement disorder consisting in hemichorea of the left...

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

Women with positive thyroid autoimmunity are considered at risk of developing hypothyroidism in pregnancy, so monitoring thyroid function is recommended.Objective: To assess the risk of gestational hypothyroidism in pregnant women with autoimmune thyroid disease and normal thyrotropin (TSH) at the beginning of pregnancy.Methods: Retrospective review of data from pregnant women attended between April 2016 and October 2019. Women wit...

Introduction: According to the latest recommendations, monitoring protocol for adrenal incidentalomas includes: hormonal determinations annually for 4 years and imaging at 6, 12 and 24 months. The objectives of this study are: i) to define the clinical features, natural history and clinical management of adrenal incidentaloma in our area, ii) to evaluate the performance of the current monitoring protocol.Methods: Retrospective study including patients di...

There is a direct relation between the degree of glycemic control and the incidence and progression of diabetic complications. In addition improving glycemic control improves diabetic complications.Aim: To assess the degree of glycemic control, according to published guidelines, in treated type 2 diabetes mellitus patients who live in a district of Madrid, Spain.Methods: Cross-sectional study in 501 consecutive patients with T2DM w...

Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from pre-diabetes and diabetes. Conflicting results currently exists on the relationship between vitamin D and glucose metabolism. Hence, the aim of our study was to investigate the association of 25-hydroxyvitamin D (25(OH)D) levels and glucose tolerance in PCOS women.Methods: Cross-sectional study including 23 PCOS patients (mean age 27 ...

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

Transforming growth factor β (TGFβ) signals through activation of Smad transcription factors, which bind to Smad binding elements (SBEs) in target genes. TGFβ can promote cancer cell proliferation and invasion, and plays a key role in the pathogenesis of scleroderma and other fibrotic disorders. We have previously shown that the thyroid hormone receptors (TRs) can block tumor growth and invasion. We now have analyzed the possibility that TRs could antagonize TGF...